April 2023 Archive: practical notes on four drug-related topics

Here’s a clear, no-fluff summary of what we published in April 2023. Each piece focuses on real-world issues — a topical treatment for skin pigment changes, chemotherapy and the liver, life-threatening overdose signs, and a steroid option for a rare skin disease. Read the short takeaways and what to do next.

Azelaic acid and vitiligo — what you need to know

We looked at azelaic acid as a topical option to manage vitiligo patches. Azelaic acid is a naturally occurring compound with anti-inflammatory and antimicrobial effects. When used on affected areas, it can reduce contrast between normal and depigmented skin and may slow the spread by affecting melanin production. If you’re curious, try a low-strength topical under a dermatologist’s guidance — skin can react differently, and a patch test helps avoid irritation. Expect gradual changes; pigment improvement usually takes weeks to months, and results vary.

Practical tip: pair azelaic acid with sun protection. Even tanning of surrounding skin makes patches more noticeable, so sunscreen helps outcomes and prevents burns.

Melphalan and liver safety

Melphalan is a chemotherapy drug that can harm the liver in some patients. Our piece covers signs to watch for, the role of regular liver function tests, and dose adjustments that doctors may use to lower risk. If you or a loved one are prescribed melphalan, ask the oncology team about baseline liver tests and how often they’ll monitor you. Some protective strategies exist, but they depend on the patient’s overall health and other meds.

Practical tip: report new symptoms like jaundice, dark urine, persistent nausea, or abdominal pain early — early detection often means safer management.

Aspirin overdose — quick recognition and what to do

Aspirin overdose can escalate fast. We highlighted common signs: rapid breathing, confusion, ringing in the ears, fever, and seizures in severe cases. If you suspect an overdose, call emergency services immediately. Don’t try home remedies like inducing vomiting; professional care can include activated charcoal if early, bicarbonate for severe acid-base problems, and supportive monitoring.

Practical tip: keep aspirin stored safely away from children and track doses when multiple people share medicine cabinets.

Betamethasone for epidermolysis bullosa

Betamethasone, a strong corticosteroid, can reduce inflammation and pain in epidermolysis bullosa flares. We covered topical and systemic uses, plus the trade-offs: steroids help symptoms but aren’t a cure and long-term use brings risks like skin thinning and hormonal effects. Work closely with a specialist to find the lowest effective dose and consider steroid-sparing options when possible.

Practical tip: focus on wound care, infection prevention, and regular follow-up rather than relying only on steroids.

Want the full posts? Check the April 2023 archive for in-depth articles, references, and practical links to help you talk with your healthcare provider.