Daclatasvir: What it does and when you might see it prescribed

Daclatasvir is an antiviral medicine used to treat chronic hepatitis C. It targets the virus’s NS5A protein, which helps the virus copy itself. Doctors usually give daclatasvir as part of a combination regimen — most commonly with sofosbuvir — because the two drugs work better together than alone.

If you’ve been told you have hepatitis C, your doctor will pick the right combination and treatment length based on the virus type (genotype), liver health, and past treatments. Typical treatment courses run from 8 to 12 weeks, but your doctor will explain what’s best for you.

How it’s taken, common side effects, and safety basics

The usual dose of daclatasvir is 60 mg once daily. Side effects most people report are mild: headache, tiredness, and nausea. Serious reactions are uncommon but can happen. If you notice sudden weakness, irregular heartbeat, severe rash, or signs of liver trouble (worsening jaundice, belly pain, dark urine), contact your provider right away.

Pregnancy and breastfeeding: there’s limited data on daclatasvir in pregnancy. If you’re pregnant, planning to become pregnant, or breastfeeding, talk to your clinician before starting therapy. Your provider will weigh risks and may recommend alternatives or extra monitoring.

Key drug interactions — what to avoid

Daclatasvir is affected by drugs that change liver enzymes, especially CYP3A4. Strong enzyme inducers — like rifampin, carbamazepine, phenytoin, and St. John’s wort — can lower daclatasvir levels and make it less effective. Some antiretrovirals and certain seizure meds fall into this group.

Strong CYP3A4 inhibitors raise daclatasvir levels and may require dose changes or closer monitoring. Always tell your prescriber about every medication, supplement, and herbal product you take. Also mention heart drugs like amiodarone — when combined with some hepatitis C drugs, there have been reports of slow heart rate, so your doctor will check if this matters for you.

Never stop or start other medicines on your own while on daclatasvir. If you’re getting care from more than one doctor, make sure they know you’re taking an HCV regimen so they can avoid risky combinations.

Thinking of buying daclatasvir online? Only use pharmacies that require a prescription and have clear contact details and licensing. Scams and counterfeit meds are common online, and the wrong product can be dangerous. If you’re unsure, ask your clinic to recommend a reputable pharmacy.

Bottom line: daclatasvir is a key tool against hepatitis C when used the right way. It’s effective and usually well tolerated, but the right partner drugs, attention to interactions, and medical supervision make the difference. If you have questions about your dose, side effects, or drug interactions, call your healthcare team — they can give advice tailored to your situation.